European consensus on grading bone marrow fibrosis and assessment of cellularity

J Thiele, HM Kvasnicka, F Facchetti, V Franco… - …, 2005 - haematologica.org
Quantification of characteristic bone marrow biopsy features includes basic parameters such
as cellularity and fiber content. These are important to assess the dynamics of disease …

Bone marrow histopathology in the diagnosis of chronic myeloproliferative disorders: a forgotten pearl

J Thiele, HM Kvasnicka, J Vardiman - Best Practice & Research Clinical …, 2006 - Elsevier
Histopathology of bone marrow (BM) biopsies plays a crucial role in the interdisciplinary
approach to diagnosis and classification of chronic myeloproliferative disorders (CMPDs) …

A critical reappraisal of the WHO classification of the chronic myeloproliferative disorders

J Thiele, HM Kvasnicka - Leukemia & lymphoma, 2006 - Taylor & Francis
Following the introduction of the WHO classification of chronic myeloproliferative disorders
(MPDs), after approximately 5 years, a critical reappraisal appears to be warranted …

Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion

C Tripodo, S Sangaletti, C Guarnotta… - Blood, The Journal …, 2012 - ashpublications.org
In myeloid malignancies, the neoplastic clone outgrows normal hematopoietic cells toward
BM failure. This event is also sustained by detrimental stromal changes, such as BM fibrosis …

Bone Marrow Features Improve Prognostic Efficiency in Multivariate Risk Classification of Chronic-Phase Ph1+ Chronic Myelogenous Leukemia: A Multicenter Trial

HM Kvasnicka, J Thiele, A Schmitt-Graeff… - Journal of clinical …, 2001 - ascopubs.org
PURPOSE: Multivariate risk classifications for chronic (stable)-phase Ph1+ chronic
myelogenous leukemia (CML) are generally focused on hematologic variables, and the …

Myelofibrosis in chronic myeloproliferative disorders--dynamics and clinical impact.

J Thiele, HM Kvasnicka - Histology and histopathology, 2006 - europepmc.org
In chronic myeloproliferative disorders, presenting or evolving myelofibrosis (MF) is
associated with significant morbidity and mortality. A systematically conducted evaluation of …

Activation of Transforming Growth Factor‐β1/p38/Smad3 Signaling in Stromal Cells Requires Reactive Oxygen Species–Mediated MMP‐2 Activity During Bone …

L Wang, S Clutter, J Benincosa, J Fortney… - Stem Cells, 2005 - academic.oup.com
Dose‐escalated chemotherapy has proven utility in a variety of treatment settings, including
preparative regimens before bone marrow or hematopoietic stem cell transplantation …

Myelofibrosis at diagnosis is associated with the failure of treatment-free remission in CML patients

H Jacobi, M Vieri, M Bütow, CY Namasu… - Frontiers in …, 2023 - frontiersin.org
The management of patients with chronic myeloid leukemia (CML) has been revolutionized
by the introduction of tyrosine kinase inhibitors (TKIs), which induce deep molecular …

Morphology of the bone marrow after stem cell transplantation

AMW Van Marion, J Thiele, HM Kvasnicka… - …, 2006 - Wiley Online Library
In many haematological conditions the only curative option is stem cell (SCT) or bone
marrow (BM) transplantation. Little information exists about BM morphology following non …

Hematologic aspects of myeloablative therapy and bone marrow transplantation

RS Riley, M Idowu, A Chesney, S Zhao… - Journal of clinical …, 2005 - Wiley Online Library
The transplantation of bone marrow cells or isolated hematopoietic stem cells from the bone
marrow or peripheral blood is a widely utilized form of therapy for patients with incurable …