Abstract Changes in pupil size at constant light levels reflect the activity of neuromodulatory
brainstem centers that control global brain state. These endogenously driven pupil dynamics …

Fast synaptic transmission relies upon the activation of ionotropic receptors by
neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play …

We do not fully understand how behavioral state modulates the processing and transmission
of sensory signals. Here, we studied the cortical representation of the retinal image in mice …

Recollection involves retrieving specific contextual details about a prior event. Functional
neuroimaging studies have identified several brain regions that are consistently more active …

Cortical circuits can flexibly change with experience and learning, but the effects on specific
cell types, including distinct inhibitory types, are not well understood. Here we investigated …

Complex cognitive abilities are thought to arise from the ability of the brain to adaptively
reconfigure its internal network structure as a function of task demands. Recent work has …

Fluctuating cognition is a complex and disabling symptom that is seen most frequently in the
context of Lewy body dementias encompassing dementia with Lewy bodies and Parkinson's …

Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Acetylcholine and noradrenaline are major neuromodulators that affect sensory processing
in the cortex. Modality-specific sensory information is processed in defined areas of the …

Throughout the nervous system, ion gradients drive fundamental processes. Yet, the roles of
interstitial ions in brain functioning is largely forgotten. Emerging literature is now revitalizing …