Periodontitis is a common inflammatory disease of infectious origins that often evolves into a
chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis …

The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic
microbial cells. The microbiota, the gut, and the brain form an association,'the microbiota-gut …

Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology
and neuroinflammation. Recently, there has been considerable interest in the role of …

Periodontitis is a chronic inflammatory disease caused by plaque that leads to alveolar bone
resorption. In the treatment of periodontitis, it is necessary to reduce the bacterial load and …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Gut microbiota represents a diverse and dynamic population of microorganisms harbouring
the gastrointestinal tract, which influences host health and disease. Bacterial colonization of …

Periodontitis is a bacterial infectious disease leading to the loss of periodontal supporting
tissues and teeth. The current guided tissue regeneration (GTR) membranes for periodontitis …

The amyloid hypothesis has dominated Alzheimer's disease (AD) research for almost 30
years. This hypothesis hinges on the predominant clinical role of the amyloid beta (Aβ) …

Objectives Microglial activation is critical for modulating the neuroinflammatory process and
the pathological progression of neurodegenerative diseases, such as Alzheimer's disease …

Alzheimer's disease (AD) is one of the most frequently diagnosed neurodegenerative
disorders worldwide and poses a major challenge for both affected individuals and their …