HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …

HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …

Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …

The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …

Latent intact HIV-1 proviruses persist in a small subset of long-lived CD4+ T cells that can
undergo clonal expansion in vivo. Expanded clones of CD4+ T cells dominate latent …

Nearly 2.3 million individuals worldwide are coinfected with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV). Odds of HCV infection are six times higher in people living …

Clonal expansion of HIV-infected cells contributes to the long-term persistence of the HIV
reservoir in ART-suppressed individuals. However, the contribution from cell clones that …

Retroviral replication proceeds through obligate integration of the viral DNA into the host
genome. In particular, for the HIV-1 genome to enter the nucleus, it must be led through the …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …