Fungi are an important but frequently overlooked cause of morbidity and mortality in
humans. Life-threatening fungal infections mainly occur in immunocompromised patients …

Background Accurate antibody tests are essential to monitor the SARS-CoV-2 pandemic.
Lateral flow immunoassays (LFIAs) can deliver testing at scale. However, reported …

Introduction Fungal disease has historically presented a diagnostic challenge due to its
often non-specific clinical presentations, relative infrequency and reliance on insensitive and …

These guidelines provide new and updated recommendations and good practice statements
in the following areas: starting ART, including initiating treatment outside the clinic and …

Cryptococcal meningitis is a leading cause of meningitis in sub-Saharan Africa. Given the
need for rapid point-of-care testing, we evaluated the diagnostic performance of the …

The mechanisms of latency in the context of C. neoformans infection remain poorly
understood. Two reasons for this gap in knowledge are: 1) the lack of standardized criteria …

Background Short-course, rifamycin-based regimens could facilitate scale-up of tuberculosis
preventive therapy (TPT), but it is unclear how stringently tuberculosis (TB) disease should …

Introduction Cryptococcal meningitis remains a significant contributor to AIDS-related
mortality despite widened access to antiretroviral therapy. Cryptococcal antigen (CrAg) can …

Despite the widespread application of point-of-care lateral flow tests, the viscosity
dependence of these assay results remains a significant challenge. Here, we employ …

Abstract Background Cryptococcal antigen (CrAg) screening with fluconazole prophylaxis
has been shown to prevent cryptococcal meningitis and mortality for people living with HIV …