Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer
Q Liu, Q Luo, A Halim, G Song - Cancer letters, 2017 - Elsevier
One of the most important metabolic hallmarks of cancer cells is deregulation of lipid
metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake …
metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake …
Oxidative stress, inflammation, and cancer: how are they linked?
S Reuter, SC Gupta, MM Chaturvedi… - Free radical biology and …, 2010 - Elsevier
Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …
The role of tumor necrosis factor in manipulating the immunological response of tumor microenvironment
The tumor microenvironment (TME) is an intricate system within solid neoplasms. In this
review, we aim to provide an updated insight into the TME with a focus on the effects of …
review, we aim to provide an updated insight into the TME with a focus on the effects of …
Radiation and ceramide-induced apoptosis
R Kolesnick, Z Fuks - Oncogene, 2003 - nature.com
Ceramide is a sphingolipid that acts as a second messenger in ubiquitous, evolutionarily
conserved, signaling systems. Emerging data suggest that radiation acts directly on the …
conserved, signaling systems. Emerging data suggest that radiation acts directly on the …
The role of vitamin D in cancer prevention and treatment
AV Krishnan, DL Trump… - Rheumatic Disease …, 2012 - rheumatic.theclinics.com
Calcitriol (1, 25-dihydroxyvitamin D3), the biologically most active form of vitamin D,
maintains calcium homeostasis through its actions in intestine, bone, kidneys, and the …
maintains calcium homeostasis through its actions in intestine, bone, kidneys, and the …
Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
MR Horsman, DW Siemann - Cancer research, 2006 - AACR
A functional vascular supply is critical for the continued growth and development of solid
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led …
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led …
Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment
AV Krishnan, D Feldman - Endocrine-Related Cancer, 2010 - erc.bioscientifica.com
Calcitriol, the hormonally active form of vitamin D, exerts multiple anti-proliferative and pro-
differentiating actions including cell cycle arrest and induction of apoptosis in many …
differentiating actions including cell cycle arrest and induction of apoptosis in many …
Importance of TNF-alpha and its alterations in the development of cancers
TNF-alpha is involved in many physiologic and pathologic cellular pathways, including
cellular proliferation, differentiation, and death, regulation of immunologic reactions to …
cellular proliferation, differentiation, and death, regulation of immunologic reactions to …
NF-κB modulation and ionizing radiation: mechanisms and future directions for cancer treatment
N Magné, RA Toillon, V Bottero, C Didelot… - Cancer letters, 2006 - Elsevier
NF-κB transcription factor regulates important cellular processes ranging from establishment
of the immune and inflammatory responses to regulation of cell proliferation or apoptosis …
of the immune and inflammatory responses to regulation of cell proliferation or apoptosis …
Sphingolipids in cancer
H Furuya, Y Shimizu, T Kawamori - Cancer and Metastasis Reviews, 2011 - Springer
The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-
phosphate (S1P) have important roles in several types of signaling and regulation of many …
phosphate (S1P) have important roles in several types of signaling and regulation of many …