One of the most important metabolic hallmarks of cancer cells is deregulation of lipid
metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

The tumor microenvironment (TME) is an intricate system within solid neoplasms. In this
review, we aim to provide an updated insight into the TME with a focus on the effects of …

Ceramide is a sphingolipid that acts as a second messenger in ubiquitous, evolutionarily
conserved, signaling systems. Emerging data suggest that radiation acts directly on the …

Calcitriol (1, 25-dihydroxyvitamin D3), the biologically most active form of vitamin D,
maintains calcium homeostasis through its actions in intestine, bone, kidneys, and the …

A functional vascular supply is critical for the continued growth and development of solid
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led …

Calcitriol, the hormonally active form of vitamin D, exerts multiple anti-proliferative and pro-
differentiating actions including cell cycle arrest and induction of apoptosis in many …

TNF-alpha is involved in many physiologic and pathologic cellular pathways, including
cellular proliferation, differentiation, and death, regulation of immunologic reactions to …

NF-κB transcription factor regulates important cellular processes ranging from establishment
of the immune and inflammatory responses to regulation of cell proliferation or apoptosis …

The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-
phosphate (S1P) have important roles in several types of signaling and regulation of many …