Merkel cell carcinoma: an immunotherapy fairy-tale?

ET Tanda, AL d'Amato, G Rossi, E Croce… - Frontiers in …, 2021 - frontiersin.org
Merkel cell carcinoma (MCC) is a rare, highly aggressive, neuroendocrine cutaneous tumor.
The incidence of MCC is growing worldwide, and the disease-related mortality is about three …

Predominance of central memory T cells with high T-cell receptor repertoire diversity is associated with response to PD-1/PD-L1 inhibition in Merkel cell carcinoma

I Spassova, S Ugurel, P Terheyden, A Sucker… - Clinical Cancer …, 2020 - AACR
Purpose: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer, which
can be effectively controlled by immunotherapy with PD-1/PD-L1 checkpoint inhibitors …

[HTML][HTML] RB1-deficient squamous cell carcinoma: The proposed source of combined Merkel cell carcinoma

RC DeCoste, NM Walsh, D Gaston, TY Ly, S Pasternak… - Modern Pathology, 2022 - Elsevier
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine (NE) carcinoma
arising from integration of Merkel cell polyomavirus (MCPyV) DNA into a host cell or from …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer

AW Silk, CA Barker, S Bhatia, KB Bollin… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Nonmelanoma skin cancers (NMSCs) are some of the most commonly diagnosed
malignancies. In general, early-stage NMSCs have favorable outcomes; however, a small …

Merkel cell carcinoma

E Dellambra, ML Carbone, F Ricci, F Ricci, FR Di Pietro… - Biomedicines, 2021 - mdpi.com
Merkel cell carcinoma (MCC) is a rare and extremely aggressive neuroendocrine carcinoma
of the skin, with increasing incidence worldwide. This review intends to propose a …

[HTML][HTML] International increases in Merkel cell carcinoma incidence rates between 1997 and 2016

CM Olsen, N Pandeya, DC Whiteman - Journal of Investigative …, 2021 - Elsevier
Relatively little is known about the epidemiology of Merkel cell carcinoma (MCC) with regard
to international trends in incidence, specifically relating to differences by age, sex, and …

Shaping the future of immunotherapy targets and biomarkers in melanoma and non-melanoma cutaneous cancers

P Spiliopoulou, O Vornicova, S Genta… - International Journal of …, 2023 - mdpi.com
Recent advances in treating cutaneous melanoma have resulted in impressive patient
survival gains. Refinement of disease staging and accurate patient risk classification have …

Distinct regulation of EZH2 and its repressive H3K27me3 mark in polyomavirus-positive and-negative Merkel cell carcinoma

MA Durand, A Drouin, A Mouchard, L Durand… - Journal of Investigative …, 2023 - Elsevier
Merkel cell carcinoma (MCC) is an aggressive skin cancer for which Merkel cell
polyomavirus integration and expression of viral oncogenes small T and Large T have been …

DNA-methylation patterns imply a common cellular origin of virus-and UV-associated Merkel cell carcinoma

J Gravemeyer, I Spassova, ME Verhaegen, AA Dlugosz… - Oncogene, 2022 - nature.com
Merkel cell carcinoma (MCC) is a neuroendocrine tumor either induced by integration of the
Merkel cell polyomavirus into the cell genome or by accumulation of UV-light-associated …

Merkel cell carcinoma: an update

RC DeCoste, MD Carter, TY Ly, JR Gruchy… - Human Pathology, 2023 - Elsevier
Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neuroendocrine
carcinoma associated with an adverse prognosis. In recent years, our understanding of …