Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neuroendocrine
carcinoma associated with an adverse prognosis. In recent years, our understanding of …

Simple Summary Merkel cell carcinoma (MCC) is an aggressive neuroendocrine cutaneous
malignancy that is well-suited for liquid biopsy due to high levels of tumor DNA shedding …

Immunotherapy, so promising in many neoplasms, still does not have a precise role in the
treatment of neuroendocrine neoplasms (NENs). In this article, we provide an overview on …

Whether Merkel cells regenerate in adult skin and from which progenitor cells they
regenerate are a subject of debate. Understanding Merkel cell regeneration is of interest to …

Simple Summary Immunotherapies have revolutionized the management of advanced stage
cancer; however, not all patients benefit given many cancers are resistant to immune …

Background Merkel cell carcinoma (MCC) is associated with high recurrence rates and poor
survival when metastatic disease is present. The immune checkpoint inhibitor avelumab has …

Simple Summary Merkel cell carcinoma (MCC) is an aggressive, rare skin cancer which is
caused either by a virus or chronic UV exposure. For both forms, distinct genetic alterations …

Background Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited
treatment possibilities. Merkel cell tumors display with neuroendocrine features and Merkel …

Tertiary lymphoid structures (TLSs) are used as biomarkers in many cancers for predicting
the prognosis and assessing the response to immunotherapy. In Merkel cell carcinoma …

Simple Summary Merkel cell carcinomas (MCCs) of unknown primary are defined as deep-
seated tumors without an associated cutaneous tumor. Although the distinction has …