[HTML][HTML] Immunoinformatics-and bioinformatics-assisted computational designing of a novel multiepitopes vaccine against cancer-causing Merkel cell polyomavirus

NM Almansour - Frontiers in Microbiology, 2022 - frontiersin.org
Merkel cell polyomavirus (MCV) contains double-stranded DNA as its genome and is the
fifth polyomavirus that infects humans. The virus causes Merkel cell carcinoma (aggressive …

[HTML][HTML] Complete response to avelumab and IL-15 superagonist N-803 with Abraxane in Merkel cell carcinoma: a case study

L Drusbosky, C Nangia, A Nguyen… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Merkel cell carcinoma (MCC) is a rare aggressive form of skin cancer originating in
neuroendocrine cells. The antiprogrammed death ligand 1 (PD-L1) monoclonal antibody …

An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response

TC Knepper, RA Panchaud, E Muradova… - Cancer …, 2021 - Wiley Online Library
Background The use of targeted therapy remains a treatment consideration for some
patients with advanced Merkel cell carcinoma (MCC). However, supportive data on the use …

[HTML][HTML] Body mass index and baseline platelet count as predictive factors in Merkel cell carcinoma patients treated with avelumab

L Incorvaia, A Dimino, L Algeri, C Brando… - Frontiers in …, 2023 - frontiersin.org
Background Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, associated
with a worse prognosis. The Immune Checkpoint Inhibitors (ICIs) avelumab and …

Immune activity in Merkel cell carcinoma

M Nakamura, A Morita - The Journal of Dermatology, 2022 - Wiley Online Library
Merkel cell carcinoma (MCC) is widely known as a highly malignant skin cancer. The
pathogenesis of MCC, however, remains mysterious due to the extremely small number of …

[HTML][HTML] T-cell responses in merkel cell carcinoma: implications for improved immune checkpoint blockade and other therapeutic options

L Gehrcken, T Sauerer, N Schaft, J Dörrie - International journal of …, 2021 - mdpi.com
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with rising incidence and
high mortality. Approximately 80% of the cases are caused by the human Merkel cell …

[HTML][HTML] Merkel cell polyomavirus in Merkel cell carcinoma: Integration sites and involvement of the KMT2D tumor suppressor gene

R Arora, JE Choi, PW Harms, P Chandrani - Viruses, 2020 - mdpi.com
Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either
Merkel cell polyomavirus (MCPyV) or UV-linked mutations. MCPyV is found integrated into …

Clinical Next-Generation Sequencing Panels Reveal Molecular Differences Between Merkel Cell Polyomavirus–Negative Merkel Cell Carcinomas and …

E Hartsough, M Mino-Kenudson… - American Journal of …, 2023 - academic.oup.com
Objectives We aim to determine molecular differences between Merkel cell polyomavirus
(MCPyV)–negative Merkel cell carcinomas (MCCs) and neuroendocrine carcinomas …

[HTML][HTML] Chromosomal Aberrations Accumulate during Metastasis of Virus-Negative Merkel Cell Carcinoma

TJ Robb, Z Ward, P Houseman, B Woodhouse… - Journal of Investigative …, 2023 - Elsevier
Merkel cell carcinoma is a rare, aggressive skin tumor initiated by polyomavirus integration
or UV light DNA damage. In New Zealand, there is a propensity toward the UV-driven form …

[HTML][HTML] Merkel cell carcinoma of the eyelid and periocular region: A review

NM Walsh - Saudi Journal of Ophthalmology, 2021 - journals.lww.com
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with a
high mortality rate. It typically affects elderly Caucasians, with a slight predilection for males …