The incidence of distant metastases in head and neck squamous cell carcinoma (SCC) is
relatively small in comparison to other malignancies. Distant metastases adversely impact …

Peripheral lymph nodes, located deep in the subcutaneous tissue, clean antigens from the
extracellular fluid. Generally, a normal sized lymph node is less than one cm in diameter …

The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we
describe a comprehensive genomic characterization of 56 primary HCC tumors that span …

Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to
radioiodine therapy that exhibits an accumulation of mitochondria. We performed whole …

Background: A risk-adapted approach to management of thyroid cancer requires risk
estimates that change over time based on response to therapy and the course of the …

Background: Distant metastases at presentation are rare in well-differentiated thyroid cancer
(WDTC). The objective of this study was to report outcomes for patients presenting with …

Background: Clinical benefit from cytotoxic chemotherapy for metastatic papillary thyroid
carcinoma (PTC) is disappointing, and effective therapeutic approaches for these patients …

Context: Hurthle cell cancer (HCC) is an understudied cancer with poor prognosis.
Objective: Our objective was to elucidate the genomic foundations of HCC. Design and …

Background Although subclinical cervical lymph node (LN) metastases in papillary thyroid
carcinoma (PTC) are common, the efficacy of prophylactic central LN dissection (CLND) is …

Abstract Objectives/Hypothesis The outcome in differentiated thyroid cancer generally
depends on the stage of the disease at the time of presentation; prognostic factors such as …