Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes

P Kanth, MW Hazel, JC Schell, J Rutter, R Yao… - Familial Cancer, 2024 - Springer
Serrated polyposis syndrome (SPS) presents with multiple sessile serrated lesions (SSL) in
the large intestine and confers increased colorectal cancer (CRC) risk. However, the …

Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp

KE Boylan, P Kanth, D Delker, MW Hazel, KM Boucher… - Human Pathology, 2023 - Elsevier
Colonic SSLs are thought to predispose to∼ 30% of colonic adenocarcinomas. This
increased risk, compared to benign HPs, makes their distinction vitally important. However …

Sessile serrated lesion detection rates continue to increase: 2008–2020

N Edwardson, P Adsul, Z Gonzalez… - Endoscopy …, 2023 - thieme-connect.com
Background and study aims We assessed sessile serrated lesion detection rate (SSLDR) at
a large academic medical center from 2008 to 2020 and modeled a local, aspirational target …

Mucin 5AC is a sensitive surface marker for sessile serrated lesions: results from a systematic review and meta-analysis

K Liu, M Sachar, V Popov, Z Pei, G Quarta - medRxiv, 2024 - medrxiv.org
Sessile serrated lesions (SSLs) are a class of colon polyps which are challenging to detect
through current screening methods but are highly associated with colon cancer. We …

An “expressionistic” look at serrated precancerous colorectal lesions

G Marra - Diagnostic pathology, 2021 - Springer
Background Approximately 60% of colorectal cancer (CRC) precursor lesions are the
genuinely-dysplastic conventional adenomas (cADNs). The others include hyperplastic …

Fascin1 accelerates serrated pathway carcinogenesis by remodeling adherens junctions and restoring Wnt signaling

A Esmaeilniakooshkghazi, E Pham, SP George… - bioRxiv, 2022 - biorxiv.org
Approximately 35% of colorectal carcinomas (CRCs) arise from sessile serrated lesions
(SSLs) which have a> 90% rate of BRAF V600E mutation. Compared to conventional CRCs …

[PDF][PDF] Pólipos serreados do cólon e reto

DIS Campos - 2020 - repositorio-aberto.up.pt
Characterized by a saw-tooth glandular profile, colorectal serrated polyps, had previously
been regarded as benign proliferations devoid of malignant potential. However, these are …

[引用][C] Sessile serrated lesion detection rates continue to increase

N Edwardson, P Adsul, Z Gonzalez, VS Pankratz… - 2023