The goal of obesity management is to improve health. Sustained weight loss of more than
10% overall bodyweight improves many of the complications associated with obesity (eg …

Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

About 1 in 10 adults worldwide are estimated to have diabetes mellitus. They are at risk of
developing life-threatening complications resulting in reduced quality of life, increased …

The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

Context Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose
cotransporter-2 inhibitors (SGLT2is) are used off-label in the management of type 1 diabetes …

Glucagon-like peptide-1 (GLP-1) is a 30-amino acid hormone secreted by L cells in the
distal ileum, colon, and pancreatic α cells, which participates in blood sugar regulation by …

Diabetes mellitus (DM) is a chronic metabolic disease caused by a complex interaction of
genetic and environmental factors and is characterized by persistent hyperglycemia. Long …