BACKGROUND Nearly five decades ago, visionary scientists hypothesized that genetic
modification by exogenous DNA might be an effective treatment for inherited human …

Recent advances in genome editing technologies have magnified the prospect of single-
dose cures for many genetic diseases. For most genetic disorders, precise DNA correction is …

Adopt a moratorium on heritable genome editing Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Clinical Genome Editing Therapeutic editing of the human genome has long been a holy
grail of genetic medicine. Different approaches are founded on a bedrock of basic laboratory …

CRISPR systems have emerged as transformative tools for altering genomes in living cells
with unprecedented ease, inspiring keen interest in increasing their specificity for perfectly …

With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …

Over the last three decades, the development of new genome editing techniques, such as
ODM, TALENs, ZFNs and the CRISPR‐Cas system, has led to significant progress in the …

A global observatory for gene editing Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Discussions and debates about the governance of human germline and heritable genome
editing should be informed by a clear and accurate understanding of the global policy …

In an era of large-scale science-related challenges and rapid advancements in
groundbreaking science with major societal implications, communicating about science is …