Enhanced long-term survival rates of young women with cancer and advances in
reproductive medicine and cryobiology have culminated in an increased interest in fertility …

In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment.
An alternative to commonly used ovarian hyperstimulation can become extracorporeal …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

BACKGROUND Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and
heterogeneous endocrine disorder in women of reproductive age. Although patients with …

Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of
what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

The physiology of oocyte in vitro maturation remains elusive. Generally, the oocytes have a
very low maturation rate under in vitro conditions. In the current study, we found that …

The oocyte plays an important role in regulating and promoting follicle growth, and thereby
its own development, by the production of oocyte growth factors that predominantly act on …

BACKGROUND A large number of studies have contributed to understanding the general
mechanisms driving ovarian folliculogenesis in humans and show a complex endocrine …

BACKGROUND Oocyte in vitro maturation (IVM) reduces the need for gonadotrophin-
induced ovarian hyperstimulation and its associated health risks but the unacceptably low …