Over the past decades, a multitude of experimental drugs have been shown to delay
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …

Mislocalization of the predominantly nuclear RNA/DNA binding protein, TDP-43, occurs in
motor neurons of~ 95% of amyotrophic lateral sclerosis (ALS) patients, but the contribution …

Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell
types are likely involved in this disease. We recently generated rNLS8 mice in which human …

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

A major feature of neurodegeneration is disruption of central nervous system homeostasis,
during which microglia play diverse roles. In the central nervous system, microglia serve as …

For decades, it has been widely believed that the blood–brain barrier (BBB) provides an
immune privileged environment in the central nervous system (CNS) by blocking peripheral …

Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …

ALS is characterized by progressive inability to execute movements. Motor neurons
innervating fast-twitch muscle-fibers preferentially degenerate. The reason for this …