The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

Rationale: Studies of excised lungs show that significant airway attrition in the “quiet” zone
occurs early in chronic obstructive pulmonary disease (COPD). Objectives: To determine if …

Rationale: Lung disease is the major cause of morbidity and mortality in persons with cystic
fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR (CF …

Chronic obstructive pulmonary disease (COPD) is associated with morphologic
abnormalities of airways with various patterns and severities. However, the way of effectively …

Background Although FEV 1 remains the gold standard for staging COPD, the association
between airway remodeling and airflow limitation remains unclear. Endobronchial optical …

Background Diesel exhaust (DE) is a major source of ultrafine particulate matters (PM) in
ambient air and contaminates many occupational settings. Airway remodeling assessed …

Rationale: Airway remodeling in chronic obstructive pulmonary disease (COPD) is due to
luminal narrowing and/or loss of airways. Existing computed tomographic metrics of airway …

Computed tomographic measures of central airway morphology have been used in clinical,
epidemiologic, and genetic investigation as an inference of the presence and severity of …

The concept that the small airway is a primary pathological site for all COPD phenotypes has
been challenged by recent findings that the disease starts from the central airways in COPD …

OBJECTIVE. The purpose of this study was to acquire normative data on central airway
dimensions on chest CT scans in the pediatric population. MATERIALS AND METHODS …