Toll-like Receptor 4 (TLR4) agonists have had a long journey in the field of cancer
immunotherapy. Nevertheless, despite the remarkable number of the TLR4 ligands that …

Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's
quality of life. Initially thought to be an immune privileged site, the spinal cord is able to …

Chronic infection with the bacterial pathogen Helicobacter pylori is a risk factor for the
development of gastric cancer, yet remains asymptomatic in the majority of individuals. We …

Coptis chinensis has been used in traditional Chinese medicine to treat inflammatory
symptoms. Berberine is the main alkaloid compound of C. chinensis. This study utilized a …

There is emerging evidence of the efficiency of probiotic, prebiotic and synbiotic treatments
in inflammatory bowel diseases (IBDs) and one of their long-term complications, colorectal …

Toll-like receptors (TLRs) are crucial pattern-recognition receptors (PRRs) for activation of
innate and adapted immunity. TLR2 heterodimerizes with TLR1 or TLR6 to recognize …

The vagus nerve can limit inflammation via the α7 nicotinic acetylcholine receptor
(α7nAChR). Selective pharmacological stimulation of the α7nAChR may have therapeutic …

Here, we investigated the ability of IFN-γ to modulate the functions of mouse neutrophils in
vitro. Neutrophils incubated in the presence of IFN-γ showed enhanced phagocytosis in …

Adult neural stem cells (NSCs) are believed to facilitate CNS repair and tissue regeneration.
However, it is not yet clear how these cells are influenced when the cellular environment is …

It is well established that the immune response to sepsis is mediated by leukocytes
associated with the innate immune system. However, there is an emerging view that T …