The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

Human memory T cell pools proliferate and differentiate at varying rates that are determined
by the frequency of lifelong antigenic re-encounter with different specific antigens. An …

Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …

ABSTRACT A number of emerging molecules and pathways have been implicated in
mediating the T-cell exhaustion characteristic of chronic viral infection. Not all dysfunctional …

Infection with hepatitis C virus (HCV) is associated with persistence in the majority of
individuals. We demonstrate here that the inhibitory molecule programmed death-1 (PD-1) is …

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a
large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of …

Repeated antigenic encounter drives proliferation and differentiation of memory T cell pools.
An important question is whether certain specific T cells may be driven eventually to …

The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is
unexplained. One factor may be the low frequency and immature phenotype of virus-specific …

Hepatitis C virus (HCV) readily establishes high‐level lifelong persistent infection in the
majority of immunocompetent adults with failure of HCV‐specific CD8+ CTL to clear viral …