Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis

G Garcia–Tsao - Gastroenterology, 2001 - Elsevier
Portal hypertension is the main complication of cir-rhosis because it is directly responsible
for two of its most common and potentially lethal complications: variceal hemorrhage and …

Renin–angiotensin–aldosterone inhibitors in the reduction of portal pressure: A systematic review and meta-analysis

P Tandon, JG Abraldes, A Berzigotti… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Renin–angiotensin–aldosterone antagonists [ACE inhibitors
(ACEi), angiotensin receptor blockers (ARB), aldosterone antagonists (AA)] are potential …

Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis

AW Schneider, JF Kalk, CP Klein - Hepatology, 1999 - Wiley Online Library
Administration of angiotensin II causes an increase in portal pressure, and plasma
concentration of angiotensin II is elevated in patients with cirrhosis, suggesting that …

Pathways of hepatic and renal damage through non‐classical activation of the renin‐angiotensin system in chronic liver disease

G Sansoè, M Aragno, F Wong - Liver International, 2020 - Wiley Online Library
In liver cirrhosis, renin‐angiotensin system (RAS) activation sustains renal sodium retention
and hepatic fibrogenesis. New information has recently enlivened the traditional concept of …

End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms

PD Arkwright, V Pravica, PJ Geraghty… - American journal of …, 2003 - atsjournals.org
The clinical course of patients with cystic fibrosis (CF) with functionally similar mutations in
the CF transmembrane conductance regulator gene is variable and must therefore relate to …

Impact of inhibitors of the Renin-Angiotensin-aldosterone system on liver fibrosis and portal hypertension

U Tox, HM Steffen - Current medicinal chemistry, 2006 - ingentaconnect.com
Morbidity and mortality of chronic liver disease are primarily caused by liver cirrhosis and
portal hypertension, both of them secondary disorders of progressive liver fibrosis. The main …

Captopril reduces portal pressure effectively in portal hypertensive patients with low portal venous velocity

SK Baik, DH Park, MY Kim, YJ Choi, HS Kim… - Journal of …, 2003 - Springer
Background The effect of an angiotensin II blockade in lowering the portal pressure in
patients with liver cirrhosis and portal hypertension is controversial. This prospective study …

Angiotensin converting enzyme inhibitors and angiotensin II antagonists as therapy in chronic liver disease

J Vlachogiannakos, AKW Tang, D Patch, AK Burroughs - Gut, 2001 - gut.bmj.com
Gut: first published as 10.1136/gut. 49.2. 303 on 1 August 2001. Downloaded from of
ascites, salt restriction, use of diuretics, and renal function impairment) it is diYcult to make …

Pharmacological treatment of portal hypertension: hemodynamic effects and prevention of bleeding

D Lebrec - Pharmacology & therapeutics, 1994 - Elsevier
In the past 10 yeats, it has been clearly shown that vasoactive substances reduce portal
pressure in patients or animals with portal hypertension. Some of these substances act by …

Efficacy of irbesartan, a receptor selective antagonist of angiotensin II, in reducing portal hypertension

W Debernardi-Venon, C Barletti, C Alessandria… - Digestive diseases and …, 2002 - Springer
The use of angiotensin II antagonists in the treatment of portal hypertension remains
controversial. Our aims were to assess the effect of Irbesartan on portal pressure and to …