Epidermal growth factor receptor (EGFR) crosstalks in liver cancer
C Berasain, MU Latasa, R Urtasun, S Goñi, M Elizalde… - Cancers, 2011 - mdpi.com
Hepatocarcinogenesis is a complex multistep process in which many different molecular
pathways have been implicated. Hepatocellular carcinoma (HCC) is refractory to …
pathways have been implicated. Hepatocellular carcinoma (HCC) is refractory to …
[HTML][HTML] Molecular dynamic simulation, free binding energy calculation of Thiazolo-[2, 3-b] quinazolinone derivatives against EGFR-TKD and their anticancer activity
Epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) plays a crucial role in
the onset and progression of different types of cancers. The existing EGFR-TKD inhibitors …
the onset and progression of different types of cancers. The existing EGFR-TKD inhibitors …
Pathways and targets in hepatocellular carcinoma
A Psyrri, N Arkadopoulos… - Expert review of …, 2012 - Taylor & Francis
The incidence of hepatocellular carcinoma (HCC) has been rising in several western low-
incidence areas over the past decade. The purpose of this review was to summarize the …
incidence areas over the past decade. The purpose of this review was to summarize the …
The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours
M Hopfner, V Baradari, A Huether… - Endocrine-Related …, 2006 - erc.bioscientifica.com
Gastrointestinal neuroendocrine tumours (NET) represent a heterogeneous tumour entity.
The anti-neoplastic therapy of advanced NET disease is still unsatisfactory and innovative …
The anti-neoplastic therapy of advanced NET disease is still unsatisfactory and innovative …
Design, synthesis and biological evaluation of cinnamamide-quinazoline derivatives as potential EGFR inhibitors to reverse T790M mutation
B Zhang, Z Xu, Q Liu, S Xia, Z Liu, Z Liao, S Gou - Bioorganic Chemistry, 2021 - Elsevier
Gatekeeper T790M mutation in EGFR is the most common factor for acquired resistance.
Acrylamide-bearing 4-anilinoquinazoline scaffold are powerful irreversible inhibitors for …
Acrylamide-bearing 4-anilinoquinazoline scaffold are powerful irreversible inhibitors for …
EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells
X Ge, Y Zhang, F Huang, Y Wu, J Pang… - Human & …, 2021 - journals.sagepub.com
Almonertinib, a new third-generation epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitor, is highly selective to EGFR T790M-mutant non-small cell lung cancer …
kinase inhibitor, is highly selective to EGFR T790M-mutant non-small cell lung cancer …
Design, synthesis, docking, ADMET and anticancer evaluations of N-alkyl substituted iodoquinazoline derivatives as dual VEGFR-2 and EGFR inhibitors
Fifteen new 1-alkyl-6-iodoquinazoline derivatives 5a–d to 9a–e were designed and
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …
[HTML][HTML] HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability
HY Dai, LS Chang, SF Yang, SN Wang… - … (New York, NY), 2023 - ncbi.nlm.nih.gov
Alterations of histone deacetylases (HDACs) have been found in various types of cancers
[1]. Among HDAC family members, HDAC6 is the only HDAC that possesses two functional …
[1]. Among HDAC family members, HDAC6 is the only HDAC that possesses two functional …
Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular level
MK Hammoud, HK Yosef, T Lechtonen, K Aljakouch… - Scientific Reports, 2018 - nature.com
Monitoring the drug efficacy or resistance in vitro is usually carried out by measuring the
response of single few proteins. However, observation of single proteins instead of an …
response of single few proteins. However, observation of single proteins instead of an …
Panitumumab-DOTA-111In: An Epidermal Growth Factor Receptor Targeted Theranostic for SPECT/CT Imaging and Meitner–Auger Electron Radioimmunotherapy of …
Epidermal growth factor receptors (EGFR) are overexpressed in triple-negative breast
cancer (TNBC) and are an attractive target for the development of theranostic …
cancer (TNBC) and are an attractive target for the development of theranostic …