Hepatocellular carcinoma (HCC) is a major cause of cancer‐related deaths. This
malignancy is often diagnosed at an advanced state, when most potentially curative …

Chemotherapy represents the most applied approach to cancer treatment. Owing to the
frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover …

Erlotinib is a small-molecular inhibitor of epidermal growth factor receptor (EGFR). Here, we
identify that cancerous inhibitor of protein phosphatase 2A (CIP2A) is a major determinant …

Ursolic acid (UA), is a kind of triterpene acid that exhibits wide biological properties. In this
article, the effects of UA on apoptosis and the proliferation of human hepatoma Huh-7 cells …

Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized
and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides …

BACKGROUND: Rapamycin, isolated from Streptomyces hygroscopicus, is recently reported
to have immunosuppressant and anti-tumor effects on a large variety of cancers. To date, no …

With the advent of personalized medicine, design and development of anti-cancer drugs that
are specifically targeted to individual or sets of genes or proteins has been an active …

Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the
extreme variability of the clinical outcome, which makes it difficult to properly stage the …

Targeted therapy refers to anticancer treatment which specifically targets key molecules of
cancer cells and/or neovascular cells, aiming to thus interfere with processes of …

Mutational acquired resistance is a major challenge in cancer therapy. Somatic tumours
harbouring some oncogenic mutations are characterised by a high mortality rate …