[HTML][HTML] Dual induction of caspase 3-and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells

H Tatsukawa, T Sano, Y Fukaya, N Ishibashi… - Molecular cancer, 2011 - Springer
Background Hepatocellular carcinoma has a high mortality rate due to its rate of recurrence.
Acyclic retinoid prevents recurrence of hepatocellular carcinoma in patients after surgical …

Targeting tyrosine kinase receptors in hepatocellular carcinoma

J Muntane, AJ De la Rosa, F Docobo… - Current cancer drug …, 2013 - ingentaconnect.com
The recent discoveries of genomic and molecular markers in hepatocellular carcinoma
(HCC) have improved the understanding about the complexity of the signal transduction …

Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma

DF Calvisi, RM Pascale, F Feo - Reviews on recent clinical …, 2007 - ingentaconnect.com
Genomic instability during hepatocarcinogenesis causes changes in signal transduction
network. Strategies for identification of new markers/therapeutic targets include discovery of …

[HTML][HTML] Adverse toxic effects of tyrosine kinase inhibitors on non-target zebrafish liver (ZFL) cells

K Kološa, B Žegura, M Štampar, M Filipič… - International Journal of …, 2023 - mdpi.com
Over the past 20 years, numerous tyrosine kinase inhibitors (TKIs) have been introduced for
targeted therapy of various types of malignancies. Due to frequent and increasing use …

Erlotinib-loaded albumin nanoparticles: A novel injectable form of erlotinib and its in vivo efficacy against pancreatic adenocarcinoma ASPC-1 and PANC-1 cell lines

M Noorani, N Azarpira, K Karimian, H Heli - International journal of …, 2017 - Elsevier
Erlotinib was loaded on albumin nanoparticles for the first time and the cytotoxic effect of the
resulting nanoparticles against ASPC-1 and PANC-1 pancreatic adenocarcinoma cell lines …

Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells

JF Zhang, JJ Liu, PQ Liu, DJ Lin, XD Li, GH Chen - Hepatology research, 2006 - Elsevier
The present study was undertaken to investigate the mechanisms of oridonin induced
apoptosis on human hepatocellular carcinoma BEL-7402 cells. BEL-7402 cells in culture …

[HTML][HTML] Targeting TF-AKT/ERK-EGFR pathway suppresses the growth of hepatocellular carcinoma

SZ Huang, MN Wei, JR Huang, ZJ Zhang… - Frontiers in …, 2019 - frontiersin.org
Tissue factor (TF) is a transmembrane glycoprotein to initiate blood coagulation and
frequently overexpressed in a variety of tumors. Our previous study has showed that the …

[HTML][HTML] Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer

A Huether, M Höpfner, AP Sutter… - World journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To examine the underlying mechanisms of erlotinib-induced growth inhibition in
hepatocellular carcinoma (HCC). METHODS: Erlotinib-induced alterations in gene …

Current discovery strategies for hepatocellular carcinoma therapeutics

Q Dai, C Zhang, Z Yuan, Q Sun… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: The global incidence of hepatocellular carcinoma (HCC) is not expected to
decline significantly over the next 30 years. And although the latest gene sequencing …

Molecular genetics and targeted therapy in hepatocellular carcinoma

EI Marks, NS Yee - Current cancer drug targets, 2016 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is a highly lethal disease, therefore effective and tolerable
treatment is urgently needed. In this article, we provide an updated review of the genetic …