EGFR signaling promotes ovarian cancer tumorigenesis, and high EGFR expression
correlates with poor prognosis. However, EGFR inhibitors alone have demonstrated limited …

Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, as well as a
common cause of cancer‐related death. HCC frequently occurs in the setting of a diseased …

FaO rat hepatoma cells show increased levels of the epidermal growth factor receptor
(EGFR) ligands, when compared with adult normal hepatocytes, and higher activity of the …

The limited efficacy of conventional cytotoxic treatment regimes for advanced
gastrointestinal neuroendocrine cancers emphasizes the need for novel and more effective …

Purpose Erlotinib hydrochloride is a small molecule inhibitor of epidermal growth factor
receptor (EGFR). EGFR is over-expressed in primary brain tumors and solid tumors that …

Hepatocellular carcinoma (HCC) is one of the world's most common and deadly cancers.
Less than one-third of patients can currently benefit from potentially curative therapies in the …

Interventions: Although phase II open-label study of cetuximab in unresectable HCC was
negative, the clinical relevance of this report by Song et al which is based on a single patient …

Genomic studies have established a set of three core-signaling pathways, receptor tyrosine
kinase (RTK), p53 and retinoblastoma (Rb) signaling pathways, contributing glioblastoma …

A series of chalcone-based 4-Nitroacetophenone derivatives were designed and
synthesized by the single-step condensation method. These compounds were identified by …

Epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target in
many cancers, and overexpression of EGFR is frequently observed in hepatocellular …