Apoptotic mechanisms of quercetin in liver cancer: recent trends and advancements
Due to rising incidence rates of liver cancer and worries about the toxicity of current
chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy …
chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy …
Proteolysis-targeting chimeras in biotherapeutics: Current trends and future applications
The success of inhibitor-based therapeutics is largely constrained by the acquisition of
therapeutic resistance, which is partially driven by the undruggable proteome. The …
therapeutic resistance, which is partially driven by the undruggable proteome. The …
[HTML][HTML] 3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property
It is still a major challenge to remove tumor cells and fill bone defects after tumor resection.
Combined with the 3D printing technology, the composite bioceramics scaffolds were …
Combined with the 3D printing technology, the composite bioceramics scaffolds were …
2-Aminobenzothiazoles in anticancer drug design and discovery
G Huang, T Cierpicki, J Grembecka - Bioorganic chemistry, 2023 - Elsevier
Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …
research efforts have been made to develop new chemical entities with improved anticancer …
BCL-G: 20 years of research on a non-typical protein from the BCL-2 family
ML Hartman, M Czyz - Cell Death & Differentiation, 2023 - nature.com
Proteins from the BCL-2 family control cell survival and apoptosis in health and disease, and
regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, also known as BCL2 …
regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, also known as BCL2 …
Nanomedicines for overcoming cancer drug resistance
T Hu, H Gong, J Xu, Y Huang, F Wu, Z He - Pharmaceutics, 2022 - mdpi.com
Clinically, cancer drug resistance to chemotherapy, targeted therapy or immunotherapy
remains the main impediment towards curative cancer therapy, which leads directly to …
remains the main impediment towards curative cancer therapy, which leads directly to …
Role of YY1 in the regulation of anti-apoptotic gene products in drug-resistant cancer cells
M Jung, I Bui, B Bonavida - Cancers, 2023 - mdpi.com
Simple Summary New treatments that utilize targeted therapeutic agents or invigorations of
the host immune system to destroy cancer cells are not effective against all cancers or …
the host immune system to destroy cancer cells are not effective against all cancers or …
New Schiff Base–TMB Hybrids: Design, synthesis and antiproliferative investigation as potential anticancer agents
NM Alyamani - Symmetry, 2023 - mdpi.com
The structural symmetry or asymmetry of organic compounds is one of the most fundamental
characteristics. Z-geometrical isomers are promiscuous and kinetically preferred structures …
characteristics. Z-geometrical isomers are promiscuous and kinetically preferred structures …
Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties
Z Zhang, S Zhao, J Pei, L Hou, S Luan, H Deng… - European Journal of …, 2023 - Elsevier
Direct activation of the pro-apoptotic protein BAX represents a potential therapeutic strategy
to trigger apoptosis in cancer. Herein, structural optimization of the reported BAX trigger site …
to trigger apoptosis in cancer. Herein, structural optimization of the reported BAX trigger site …
Water-soluble copper (II) 5-fluorouracil complexes bearing polypyridyl co-ligands: synthesis, structures and anticancer activity
Five newly synthesized copper (II) 5-fluorouracil (5-FU) complexes of polypyridyl co-ligands
with good solubility in water, namely [CuCl (5-FU)(bpy)(DMSO)](1),[Cu (5-FU)(phen) 2](5 …
with good solubility in water, namely [CuCl (5-FU)(bpy)(DMSO)](1),[Cu (5-FU)(phen) 2](5 …