Due to rising incidence rates of liver cancer and worries about the toxicity of current
chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy …

The success of inhibitor-based therapeutics is largely constrained by the acquisition of
therapeutic resistance, which is partially driven by the undruggable proteome. The …

It is still a major challenge to remove tumor cells and fill bone defects after tumor resection.
Combined with the 3D printing technology, the composite bioceramics scaffolds were …

Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …

Proteins from the BCL-2 family control cell survival and apoptosis in health and disease, and
regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, also known as BCL2 …

Clinically, cancer drug resistance to chemotherapy, targeted therapy or immunotherapy
remains the main impediment towards curative cancer therapy, which leads directly to …

Simple Summary New treatments that utilize targeted therapeutic agents or invigorations of
the host immune system to destroy cancer cells are not effective against all cancers or …

The structural symmetry or asymmetry of organic compounds is one of the most fundamental
characteristics. Z-geometrical isomers are promiscuous and kinetically preferred structures …

Direct activation of the pro-apoptotic protein BAX represents a potential therapeutic strategy
to trigger apoptosis in cancer. Herein, structural optimization of the reported BAX trigger site …

Five newly synthesized copper (II) 5-fluorouracil (5-FU) complexes of polypyridyl co-ligands
with good solubility in water, namely [CuCl (5-FU)(bpy)(DMSO)](1),[Cu (5-FU)(phen) 2](5 …