Quantitative gait and balance outcomes for ataxia trials: consensus recommendations by the ataxia global initiative working group on digital-motor biomarkers
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid,
finely granulated, digital health measures are highly warranted to augment clinical and …
finely granulated, digital health measures are highly warranted to augment clinical and …
At-home wearables and machine learning sensitively capture disease progression in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis causes degeneration of motor neurons, resulting in
progressive muscle weakness and impairment in motor function. Promising drug …
progressive muscle weakness and impairment in motor function. Promising drug …
Ataxia rating scales reflect patient experience: an examination of the relationship between clinician assessments of cerebellar ataxia and patient-reported outcomes
MH Potashman, ML Mize, MW Beiner, S Pierce, V Coric… - The Cerebellum, 2023 - Springer
Ataxia rating scales are observer administered clinical outcome assessments (COAs) of the
cerebellar motor syndrome. It is not known whether these COAs mirror patient experience of …
cerebellar motor syndrome. It is not known whether these COAs mirror patient experience of …
Detection and assessment of point-to-point movements during functional activities using deep learning and kinematic analyses of the stroke-affected wrist
Stoke is a leading cause of long-term disability, including upper-limb hemiparesis. Frequent,
unobtrusive assessment of naturalistic motor performance could enable clinicians to better …
unobtrusive assessment of naturalistic motor performance could enable clinicians to better …
A wearing orientation-independent electromagnetic self-powered sensor for human activity recognition based on biomechanical energy scavenging
S Fan, Y Tang, H Chi, D Hou, G Zhang, Y Cao - Measurement, 2024 - Elsevier
Self-powered human activity recognition (HAR) using vibration energy harvesters attracts
broad interest in wearable electronics. To address the challenge of making such sensors …
broad interest in wearable electronics. To address the challenge of making such sensors …
Real-life ankle submovements and computer mouse use reflect patient-reported function in adult ataxias
Novel disease-modifying therapies are being evaluated in spinocerebellar ataxias and
multiple system atrophy. Clinician-performed disease rating scales are relatively insensitive …
multiple system atrophy. Clinician-performed disease rating scales are relatively insensitive …
Understanding voluntary human movement variability through data-driven segmentation and clustering
Recently, we proposed a novel approach where movements are decomposed into sub-
segments, termed movement elements. This approach, to date, provides a robust construct …
segments, termed movement elements. This approach, to date, provides a robust construct …
Sensitive quantification of cerebellar speech abnormalities using deep learning models
Objective, sensitive, and meaningful disease assessments are critical to support clinical
trials and clinical care. Speech changes are one of the earliest and most evident …
trials and clinical care. Speech changes are one of the earliest and most evident …
Technological evolution in the instrumentation of ataxia severity measurement
Cerebellar ataxia is the poorly coordinated movement that results from injury or disease
affecting the cerebellum. The diagnosis and assessment of ataxia are significantly …
affecting the cerebellum. The diagnosis and assessment of ataxia are significantly …
Estimation of ataxia severity in children with ataxia-telangiectasia using ankle-worn sensors
Ataxia-telangiectasia (AT) is a neurodegenerative disease characterized by onset of ataxia
in early childhood with impairments in gait, balance, and coordination [1]. As drug …
in early childhood with impairments in gait, balance, and coordination [1]. As drug …