The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

There are a large number of bacteria inhabiting the human body, which provide benefits for
the health. Alterations of microbiota participate in the pathogenesis of diseases. The gastric …

In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

Timing is essential for many cellular processes, from cellular responses to external stimuli to
the cell cycle and circadian clocks. Many of these processes are based on gene expression …

How the noisy expression of regulatory proteins affects timing of intracellular events is an
intriguing fundamental problem that influences diverse cellular processes. Here we use the …

Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

Many cellular events occur when their corresponding regulatory proteins attain critical
thresholds. Can cells schedule such events with precision by controlling the dynamics of the …

Development is a process precisely coordinated in both space and time. Spatial precision
has been quantified in a number of developmental systems, and such data have contributed …

Important cellular processes such as migration, differentiation, and development often rely
on precise timing. Yet, the molecular machinery that regulates timing is inherently noisy …

Microbial populations can adapt to adverse environmental conditions either by appropriately
sensing and responding to the changes in their surroundings or by stochastically switching …