Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

Abstract Micro Capture-C (MCC) is a chromatin conformation capture (3C) method for
visualizing reproducible three-dimensional contacts of specified regions of the genome at …

Although enhancers are central regulators of mammalian gene expression, the mechanisms
underlying enhancer–promoter (EP) interactions remain unclear. Chromosome …

Much progress has been made recently in single-cell chromosome conformation capture
technologies. However, a method that allows simultaneous profiling of chromatin …

The relationship between chromatin organization and gene regulation remains unclear.
While disruption of chromatin domains and domain boundaries can lead to misexpression of …

Enhancers and promoters predominantly interact within large-scale topologically
associating domains (TADs), which are formed by loop extrusion mediated by cohesin and …

Super-enhancers are compound regulatory elements that control expression of key cell
identity genes. They recruit high levels of tissue-specific transcription factors and co …

Enhancer-mediated gene activation generally requires physical proximity between
enhancers and their target gene promoters. However, the molecular mechanisms by which …

Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation
of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter …

BCL11A, the major regulator of fetal hemoglobin (HbF, α2γ2) level, represses γ-globin
expression through direct promoter binding in adult erythroid cells in a switch to adult …