Blood is a tissue with high cellular turnover, and its production is a tightly orchestrated
process that requires constant replenishment. All mature blood cells are generated from …

The transforming growth factor (TGF-β) family of growth factors controls an immense number
of cellular responses and figures prominently in development and homeostasis of most …

Smads are signal transducers for the members of the transforming growth factor-β (TGF-β)
superfamily. Bone morphogenetic proteins (BMPs) and their receptors induce differentiation …

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …

There has been a remarkable explosion of knowledge into the molecular defects that
underlie the acute and chronic leukemias, leading to the introduction of targeted therapies …

Signaling from transforming growth factor-β (TGF-β) through its unique transmembrane
receptor serine–threonine kinases plays a complex role in carcinogenesis, having both …

The RUNX genes have come to prominence recently because of their roles as essential
regulators of cell fate in development and their paradoxical effects in cancer, in which they …

Transforming growth factor‐β (TGF‐β) family members which include TGF‐βs, activins, and
bone morphogenetic proteins (BMPs) regulate a broad spectrum of biological responses on …

Inappropriate expression of EVI1 (ecotropic virus integration-1), in particular splice form
EVI1-1D, through chromosome 3q26 lesions or other mechanisms has been implicated in …

Purpose To determine an optimal biologic dose (OBD) of decitabine as a single agent and
then the maximum-tolerated dose (MTD) of valproic acid (VA) combined with decitabine in …