[HTML][HTML] The past, present and future of anti-malarial medicines

EG Tse, M Korsik, MH Todd - Malaria journal, 2019 - Springer
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Antimalarial drug discovery: Progress and approaches

JL Siqueira-Neto, KJ Wicht, K Chibale… - Nature Reviews Drug …, 2023 - nature.com
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

[HTML][HTML] Functional profiling of a Plasmodium genome reveals an abundance of essential genes

E Bushell, AR Gomes, T Sanderson, B Anar, G Girling… - Cell, 2017 - cell.com
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA …

JF Armstrong, E Faccenda, SD Harding… - Nucleic acids …, 2020 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …

Current vector control challenges in the fight against malaria

G Benelli, JC Beier - Acta tropica, 2017 - Elsevier
The effective and eco-friendly control of Anopheles vectors plays a key role in any malaria
management program. Integrated Vector Management (IVM) suggests making use of the full …

Antimalarial drug resistance and novel targets for antimalarial drug discovery

MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …

[HTML][HTML] Drugs in development for malaria

EA Ashley, AP Phyo - Drugs, 2018 - Springer
The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Recent progress in the development of new antimalarial drugs with novel targets

TM Belete - Drug design, development and therapy, 2020 - Taylor & Francis
Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …

[HTML][HTML] Challenges and recent progress in drug discovery for tropical diseases

M De Rycker, B Baragaña, SL Duce, IH Gilbert - Nature, 2018 - nature.com
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …

[HTML][HTML] malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …