Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)
Z Zhan, S Li, W Chu, S Yin - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2013 to 2021 As the characteristic metabolites of Euphorbia plants, Euphorbia
diterpenoids have always been a hot topic in related science communities due to their …
diterpenoids have always been a hot topic in related science communities due to their …
Plant terpene specialized metabolism: complex networks or simple linear pathways?
From the perspectives of pathway evolution, discovery and engineering of plant specialized
metabolism, the nature of the biosynthetic routes represents a critical aspect. Classical …
metabolism, the nature of the biosynthetic routes represents a critical aspect. Classical …
Natural product-inspired targeted protein degraders: advances and perspectives
J Li, Z Cai, XW Li, C Zhuang - Journal of Medicinal Chemistry, 2022 - ACS Publications
Targeted protein degradation (TPD), a promising therapeutic strategy in drug discovery, has
great potential to regulate the endogenous degradation of undruggable targets with small …
great potential to regulate the endogenous degradation of undruggable targets with small …
[HTML][HTML] Antibacterial and antifungal terpenes from the medicinal angiosperms of Asia and the Pacific: Haystacks and gold needles
C Wiart, G Kathirvalu, CS Raju, V Nissapatorn… - Molecules, 2023 - mdpi.com
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the
Pacific with antibacterial and/or antifungal activities and analyses their distribution …
Pacific with antibacterial and/or antifungal activities and analyses their distribution …
[PDF][PDF] Antiviral properties of diterpenes and their derivatives
OI Yarovaya, SS Laev, NF Salakhutdinov - Russ. Chem. Rev, 2023 - researchgate.net
Virus is a noncellular infectious agent that reproduces only inside living cells. Viruses infect
various types of organisms such as bacteria, plants, animals and humans. The officially …
various types of organisms such as bacteria, plants, animals and humans. The officially …
Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade
MJ Classen, B Kicin, VAP Ruf… - Journal of the …, 2023 - ACS Publications
A total synthesis of the ingenane-derived diterpenoid (+)-euphorikanin A is described. Key to
the strategy is a stereocontrolled one-pot sequence consisting of transannular aldol addition …
the strategy is a stereocontrolled one-pot sequence consisting of transannular aldol addition …
Gene discovery and virus-induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids in Euphorbia peplus
T Czechowski, E Forestier… - Proceedings of the …, 2022 - National Acad Sciences
Most macro-and polycyclic Euphorbiaceae diterpenoids derive from the common C20
precursor casbene. While the biosynthetic pathway from casbene to the lathyrane jolkinol C …
precursor casbene. While the biosynthetic pathway from casbene to the lathyrane jolkinol C …
[HTML][HTML] New Insights on Euphorbia dendroides L. (Euphorbiaceae): Polyphenol Profile and Biological Properties of Hydroalcoholic Extracts from Aerial Parts
A Smeriglio, M Denaro, D Trombetta, S Ragusa… - Plants, 2021 - mdpi.com
Euphorbia dendroides L. is a rounded shrub commonly found in the Mediterranean area
well-known, since ancient times, for its traditional use. The aim of the present study was to …
well-known, since ancient times, for its traditional use. The aim of the present study was to …
Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk-1 Pathway
Y Yang, M Zhou, D Wang, X Liu, X Ye… - Journal of Natural …, 2021 - ACS Publications
Twelve undescribed jatrophane diterpenoids, euphpepluones A–L (1–12), together with
seven known analogues (13–19), were isolated from the whole plant of Euphorbia peplus …
seven known analogues (13–19), were isolated from the whole plant of Euphorbia peplus …
[HTML][HTML] Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells
K Shari, RA El Gedaily, RM Allam, KM Meselhy… - … Medicine and Therapies, 2023 - Springer
Background Breast cancer is a prevalent malignant tumor that affects women worldwide.
The primary challenge in treating breast cancer is combating drug resistance, which …
The primary challenge in treating breast cancer is combating drug resistance, which …