Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier
J Waschke, S Burger, FRE Curry, D Drenckhahn… - Histochemistry and cell …, 2006 - Springer
We have demonstrated previously that the Rho family GTPase Rac-1 is required for
maintenance of endothelial barrier functions in mouse microvascular myocardial endothelial …
maintenance of endothelial barrier functions in mouse microvascular myocardial endothelial …
Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells
N Golenhofen, W Ness, EF Wawrousek… - Histochemistry and cell …, 2002 - Springer
Stress-induced development of enhanced tolerance against various kinds of stresses has
been observed in vascular endothelial cells as well as in several other cell types. Stress …
been observed in vascular endothelial cells as well as in several other cell types. Stress …
Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso‐occlusion
RAO Montes, JR Eckman, LL Hsu… - American journal of …, 2002 - Wiley Online Library
Under venular flow conditions, sickle cell adherence to endothelium is mediated by cell
adhesion molecules and adhesive proteins associated with inflammation, coagulation, and …
adhesion molecules and adhesive proteins associated with inflammation, coagulation, and …
Computational modeling of shear forces and experimental validation of endothelial cell responses in an orbital well shaker system
Vascular endothelial cells are continuously exposed to hemodynamic shear stress. Intensity
and type of shear stress are highly relevant to vascular physiology and pathology. Here, we …
and type of shear stress are highly relevant to vascular physiology and pathology. Here, we …
[HTML][HTML] Multiplex, high-throughput method to study cancer and immune cell mechanotransduction
AR Fabiano, SC Robbins, SV Knoblauch… - Communications …, 2024 - nature.com
Studying cellular mechanoresponses during cancer metastasis is limited by sample
variation or complex protocols that current techniques require. Metastasis is governed by …
variation or complex protocols that current techniques require. Metastasis is governed by …
A cone-plate apparatus for the in vitro biochemical and molecular analysis of the effect of shear stress on adherent cells
AM Malek, R Ahlquist, GH Gibbons, VJ Dzau… - Methods in cell …, 1995 - Springer
Living cells are constantly exposed to a variety of complex mechanical stimuli which are
though to be critical in the control of tissue structure and function. Endothelial and smooth …
though to be critical in the control of tissue structure and function. Endothelial and smooth …
Physiological hydrostatic pressure protects endothelial monolayer integrity
K Muller-Marschhausen, J Waschke… - American Journal of …, 2008 - journals.physiology.org
Endothelial monolayer integrity is required to maintain endothelial barrier functions and has
found to be impaired in several disorders like inflammatory edema, allergic shock, or …
found to be impaired in several disorders like inflammatory edema, allergic shock, or …
Ca2+ dependency of N-cadherin function probed by laser tweezer and atomic force microscopy
W Baumgartner, N Golenhofen… - Journal of …, 2003 - Soc Neuroscience
This study was undertaken to provide a biophysical basis for the hypothesis that activity-
dependent modulation of cadherin-mediated adhesion by transient changes of extracellular …
dependent modulation of cadherin-mediated adhesion by transient changes of extracellular …
Vascular cell adhesion molecule-1 expression in endothelial cells exposed to physiological coronary wall shear stresses
LM O'Keeffe, G Muir, AV Piterina, T McGloughlin - 2009 - asmedigitalcollection.asme.org
Atherosclerosis is consistently found in bifurcations and curved segments of the circulatory
system, indicating disturbed hemodynamics may participate in disease development. In vivo …
system, indicating disturbed hemodynamics may participate in disease development. In vivo …
Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro
J Waschke, D Drenckhahn… - American Journal of …, 2004 - journals.physiology.org
We demonstrated previously that inhibition of the small GTPase Rac-1 by Clostridium
sordellii lethal toxin (LT) increased the hydraulic conductivity (L p) of rat venular …
sordellii lethal toxin (LT) increased the hydraulic conductivity (L p) of rat venular …