We have demonstrated previously that the Rho family GTPase Rac-1 is required for
maintenance of endothelial barrier functions in mouse microvascular myocardial endothelial …

Stress-induced development of enhanced tolerance against various kinds of stresses has
been observed in vascular endothelial cells as well as in several other cell types. Stress …

Under venular flow conditions, sickle cell adherence to endothelium is mediated by cell
adhesion molecules and adhesive proteins associated with inflammation, coagulation, and …

Vascular endothelial cells are continuously exposed to hemodynamic shear stress. Intensity
and type of shear stress are highly relevant to vascular physiology and pathology. Here, we …

Studying cellular mechanoresponses during cancer metastasis is limited by sample
variation or complex protocols that current techniques require. Metastasis is governed by …

Living cells are constantly exposed to a variety of complex mechanical stimuli which are
though to be critical in the control of tissue structure and function. Endothelial and smooth …

Endothelial monolayer integrity is required to maintain endothelial barrier functions and has
found to be impaired in several disorders like inflammatory edema, allergic shock, or …

This study was undertaken to provide a biophysical basis for the hypothesis that activity-
dependent modulation of cadherin-mediated adhesion by transient changes of extracellular …

Atherosclerosis is consistently found in bifurcations and curved segments of the circulatory
system, indicating disturbed hemodynamics may participate in disease development. In vivo …

We demonstrated previously that inhibition of the small GTPase Rac-1 by Clostridium
sordellii lethal toxin (LT) increased the hydraulic conductivity (L p) of rat venular …