Volumetric muscle loss (VML) injuries are prevalent in civilian and military trauma patients
and are known to impart chronic functional deficits. The frank loss of muscle tissue that …

Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell
adhesion. Syndecan-3-/-mice exhibit a novel form of muscular dystrophy characterized by …

Muscle regeneration requires the coordinated interaction of multiple cell types. Satellite cells
have been implicated as the primary stem cell responsible for regenerating muscle, yet the …

A dominant histopathological feature in neuromuscular diseases, including amyotrophic
lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA …

Stem cells ensure tissue regeneration, while overgrowth of adipogenic cells may
compromise organ recovery and impair function. In myopathies and muscle atrophy …

Our aim in the current study was to determine the necessity of satellite cells for long-term
muscle growth and maintenance. We utilized a transgenic Pax7-DTA mouse model …

With the explosion of knowledge from molecular biology and the burgeoning interest in
generating or regenerating tissues or organs through various bioengineering or stem cell …

Skeletal muscle stem cells, or" satellite cells"(SCs), are required for the regeneration of
damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that …

MicroRNAs (miRNAs) have emerged as key regulators of skeletal myogenesis, but our
knowledge of the identity of the myogenic miRNAs and their targets remains limited. In this …

Preparation of three-dimensional (3D) micropatterned porous scaffolds remains a great
challenge for engineering of highly organized tissues such as skeletal muscle tissue and …