With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Gene editing technologies (GETs) could induce gene knockdown or gene knockout for
biomedical applications. The clinical success of gene silence by RNAi therapies pays …

Introduction Despite the clinical success in vascularized composite allotransplantation
(VCA), systemic immunosuppression remains necessary to prevent allograft rejection. Even …

The current standard method for type 1 diabetes (T1D) management majorly focuses on
controlling blood glucose levels with exogeneous insulin administration. Recent …

Organ transplantation is the definitive treatment for end‐stage solid organ diseases, yet
biological and logistical barriers reduce the rate of successful organ transplants. As such …

Over the last century, there have been major landmark developments in the field of
medicine, enabling us to control and cure various diseases on a larger scale. A few of these …

Gene therapy has been used successfully in a diverse array of diseases, and, more recently,
this technique has gained interest in the field of organ transplantation. Biological and …

Engineering donor organs to better tolerate the harmful non-immunological and
immunological responses inherently related to solid organ transplantation would improve …

Ex vivo machine perfusion (EVMP) is rapidly growing in utility during solid organ
transplantation. This form of organ preservation is transforming how organs are allocated …

This month's installment of “The AJT Report” discusses recent groundbreaking
developments in pig‐to‐human organ transplants and explores how the current system …