Growing evidence suggests that a pressure‐induced increase in the synthesis of endothelin
(ET‐1) is involved in arterial remodeling and, as a consequence, in the manifestation of …

Umami peptides can help reduce the salt content in foods while still maintaining a savory
taste. Few studies have reported the bioactivity of umami peptides after consumption. We …

Systemic arterial pressure is a dynamic and reactive physiological parameter depending on
a great many factors. The endothelial cells of the vascular system are responsible for many …

The functional activity of umami peptides after digestion is poorly known. We studied the
dipeptidyl peptidase-4 (DPP-IV) and angiotensin I-converting enzyme (ACE) inhibition …

Cocaine remains the most frequently used illicit substance. Although cocaine-induced
atherosclerosis is well documented, its mechanism of action on human vascular endothelial …

Effects of sitaxsentan (TBC11251), an orally active, highly selective antagonist of endothelin
A receptors, were examined on the development and maintenance of pulmonary …

Objective: To investigate the maturation of the paracrine system's endothelial nitric oxide
synthase (eNOS), inducible NOS (iNOS), endothelin-1 (ET-1) and adrenomedullin (AM) in …

Endothelin-1 (ET-1) is a 21-amino acid peptide that binds to G-protein-coupled receptors to
evoke biological responses. This report studies the effect of ET-1 on regulating glucose …

Maintaining cerebrovascular function is a priority for reducing damage following acute
ischemic events such as stroke, and under chronic stress in diseases such as hypertension …

Purpose: A growing body of evidence suggests that the vasoactive peptides endothelins
(ETs) and their receptors (primarily the ET B receptor) are contributors to neurodegeneration …