Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Polymer scaffolds facilitate spinal cord injury repair

Q Zhang, B Shi, J Ding, L Yan, JP Thawani, C Fu… - Acta biomaterialia, 2019 - Elsevier
During the past decades, improving patient neurological recovery following spinal cord
injury (SCI) has remained a challenge. An effective treatment for SCI would not only reduce …

Regenerative rehabilitation with conductive biomaterials for spinal cord injury

EA Kiyotake, MD Martin, MS Detamore - Acta biomaterialia, 2022 - Elsevier
The individual approaches of regenerative medicine efforts alone and rehabilitation efforts
alone have not yet fully restored function after severe spinal cord injury (SCI). Regenerative …

[HTML][HTML] Filling the gap: neural stem cells as a promising therapy for spinal cord injury

IM Pereira, A Marote, AJ Salgado, NA Silva - Pharmaceuticals, 2019 - mdpi.com
Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …

Defined alginate hydrogels support spinal cord organoid derivation, maturation, and modeling of spinal cord diseases

WH Chooi, CY Ng, V Ow, J Harley, W Ng… - Advanced …, 2023 - Wiley Online Library
In the process of generating organoids, basement membrane extracts or Matrigel are often
used to encapsulate cells but they are poorly defined and contribute to reproducibility …

[HTML][HTML] Advances in tissue engineering and innovative fabrication techniques for 3-D-structures: translational applications in neurodegenerative diseases

F Rey, B Barzaghini, A Nardini, M Bordoni, GV Zuccotti… - Cells, 2020 - mdpi.com
In the field of regenerative medicine applied to neurodegenerative diseases, one of the most
important challenges is the obtainment of innovative scaffolds aimed at improving the …

Recent advances in the regenerative approaches for traumatic spinal cord injury: materials perspective

WA Abbas, ME Ibrahim, M El-Naggar… - ACS Biomaterials …, 2020 - ACS Publications
Spinal cord injury (SCI) is a devastating health condition that may lead to permanent
disabilities and death. Understanding the pathophysiological perspectives of traumatic SCI …

[HTML][HTML] CNS organoid surpasses cell-laden microgel assembly to promote spinal cord injury repair

Z Wang, H Zhao, X Tang, T Meng, D Khutsishvili, B Xu… - Research, 2022 - spj.science.org
The choice of therapeutic agents remains an unsolved issue in the repair of spinal cord
injury. In this work, various agents and configurations were investigated and compared for …

[HTML][HTML] Current concepts of neural stem/progenitor cell therapy for chronic spinal cord injury

H Suzuki, Y Imajo, M Funaba, N Nishida… - Frontiers in Cellular …, 2022 - frontiersin.org
Chronic spinal cord injury (SCI) is a devastating condition that results in major neurological
deficits and social burden. It continues to be managed symptomatically, and no real …

[HTML][HTML] The role of graphene oxide nanocarriers in treating gliomas

B Wang, H Guo, H Xu, Y Chen, G Zhao, H Yu - Frontiers in oncology, 2022 - frontiersin.org
Gliomas are the most common primary malignant tumors of the central nervous system, and
their conventional treatment involves maximal safe surgical resection combined with …