Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications—a review
NHL Chua, KC Vissers, ME Sluijter - Acta neurochirurgica, 2011 - Springer
Background The objective of this review is to evaluate the efficacy of Pulsed Radiofrequency
(PRF) treatment in chronic pain management in randomized clinical trials (RCTs) and well …
(PRF) treatment in chronic pain management in randomized clinical trials (RCTs) and well …
Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence
Background. Infant and under-5 childhood mortality rates in developing countries have
declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and …
declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and …
Emulation of randomized clinical trials with nonrandomized database analyses: results of 32 clinical trials
Importance Nonrandomized studies using insurance claims databases can be analyzed to
produce real-world evidence on the effectiveness of medical products. Given the lack of …
produce real-world evidence on the effectiveness of medical products. Given the lack of …
Randomized, controlled trials, observational studies, and the hierarchy of research designs
Background In the hierarchy of research designs, the results of randomized, controlled trials
are considered to be evidence of the highest grade, whereas observational studies are …
are considered to be evidence of the highest grade, whereas observational studies are …
Early enteral feeding, compared with parenteral, reduces postoperative septic complications the results of a meta-analysis
FA MOORE, DV FELICIANO, RJ ANDRASSY… - Annals of …, 1992 - journals.lww.com
This two-part meta-analysis combined data from eight prospective randomized trials
designed to compare the nutritional efficacy of early enteral (TEN) and parenteral (TPN) …
designed to compare the nutritional efficacy of early enteral (TEN) and parenteral (TPN) …
Discrepancies between meta-analyses and subsequent large randomized, controlled trials
J LeLorier, G Gregoire, A Benhaddad… - … England Journal of …, 1997 - Mass Medical Soc
Background Meta-analyses are now widely used to provide evidence to support clinical
strategies. However, large randomized, controlled trials are considered the gold standard in …
strategies. However, large randomized, controlled trials are considered the gold standard in …
A consumer's guide to subgroup analyses
▪ The extent to which a clinician should believe and act on the results of subgroup analyses
of data from randomized trials or meta-analyses is controversial. Guidelines are provided in …
of data from randomized trials or meta-analyses is controversial. Guidelines are provided in …
Users' guides to the medical literature: I. How to get started
CLINICAL SCENARIO You are a primary care physician inspired by a recent editorial
inJAMAabout lifelong learning. 1 You decide to use some of the time you normally take for …
inJAMAabout lifelong learning. 1 You decide to use some of the time you normally take for …
Users' guides to the medical literature: VI. How to use an overview
CLINICAL SCENARIO A 55-year-old man had his serum cholesterol level measured at a
shopping mall 2 months ago. His cholesterol level was elevated and he comes to you, his …
shopping mall 2 months ago. His cholesterol level was elevated and he comes to you, his …
Randomized Controlled Trials and real life studies. Approaches and methodologies: a clinical point of view.
S Saturni, F Bellini, F Braido, P Paggiaro… - Pulmonary …, 2014 - Elsevier
Abstract Randomized Controlled Trials (RCTs) are the “gold standard” for evaluating
treatment outcomes providing information on treatments “efficacy”. They are designed to test …
treatment outcomes providing information on treatments “efficacy”. They are designed to test …