The role of the epithelium in airway remodeling in asthma

DE Davies - Proceedings of the American Thoracic Society, 2009 - atsjournals.org
The bronchial epithelium is the barrier to the external environment and plays a vital role in
protection of the internal milieu of the lung. It functions within the epithelial-mesenchymal …

Review on the development of genotyping methods for assessing farm animal diversity

W Yang, X Kang, Q Yang, Y Lin, M Fang - Journal of animal science and …, 2013 - Springer
Advances in molecular biotechnology have introduced new generations of molecular
markers for use in the genetic improvement of farm animals. Consequently, more accurate …

Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

H Jongepier, HM Boezen, A Dijkstra… - Clinical & …, 2004 - Wiley Online Library
Background Asthma is a genetically complex disease characterized by respiratory
symptoms, intermittent airway obstruction and airway hyper‐responsiveness due to airway …

A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population

CC van Diemen, DS Postma, JM Vonk… - American journal of …, 2005 - atsjournals.org
Rationale: A disintegrin and metalloprotease 33 (ADAM33) has been identified as a
susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene …

[PDF][PDF] Molecular markers: An introduction and applications

FR Al-Samarai, AA Al-Kazaz - European journal of molecular …, 2015 - researchgate.net
It has introduced new generations of molecular markers for use in the genetic improvement
of farm animals. These markers provide more accurate genetic information and better …

Increased expression of ADAM33 and ADAM8 with disease progression in asthma

SC Foley, AK Mogas, R Olivenstein, PO Fiset… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: ADAM33, a disintegrin and metalloproteinase 33 gene, has been identified
as a risk factor for asthma and bronchial hyperresponsiveness and has been postulated as a …

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

ST Holgate, DE Davies, RM Powell… - European …, 2007 - Eur Respiratory Soc
While asthma is an inflammatory disorder of the airways usually associated with atopy, an
important additional component is involvement of the epithelium and underlying …

Time to draw breath: asthma-susceptibility genes are identified

M Wills-Karp, SL Ewart - Nature Reviews Genetics, 2004 - nature.com
The prevalence of complex genetic immune disorders, such as asthma, arthritis and
diabetes, has escalated in recent decades. Despite the formidable challenges posed by the …

Polymorphisms in A Disintegrin and Metalloprotease 33 (ADAM33) Predict Impaired Early-Life Lung Function

A Simpson, N Maniatis, F Jury… - American journal of …, 2005 - atsjournals.org
Rationale: Asthma commonly originates in early life in association with impaired lung
function, which tracks to adulthood. Objectives: Within the context of a prospective birth …

Genotyping single nucleotide polymorphisms by MALDI mass spectrometry in clinical applications

J Tost, IG Gut - Clinical biochemistry, 2005 - Elsevier
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry
has become one of the most powerful and widely applied technologies for SNP scoring and …