Activin and myostatin are related members of the TGF-β growth factor superfamily. FSTL3
(Follistatin-like 3) is an activin and myostatin antagonist whose physiological role in adults …

Myostatin plays a major role in muscle growth and development and animals with disruption
of this gene display marked increases in muscle mass. Little is known about muscle …

Aims Myostatin inhibits myoblast differentiation/proliferation and may play a role in heart
failure (HF) and reverse remodelling after left ventricular assist device (LVAD) support. This …

Recent high-profile studies report conflicting data on the age-related change in circulating
growth/differentiation factor 11 (GDF11) and myostatin as well as the former's influence on …

The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent
condition among the elderly. Although the molecular mechanisms underlying sarcopenia …

Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in
many species, from rodents to humans, although its mechanisms of action are incompletely …

Myostatin, a TGF-β family member, is an important regulator of adult muscle size. While
extensively studied in vitro, the mechanisms by which this molecule mediates its effect in …

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth.
However, myostatin has been also involved in several forms of muscle wasting in adulthood …

Endocrine regulation of the balance between skeletal muscle anabolism and catabolism has
been investigated extensively. Factors determining whether hormones exert anabolic or …

Myostatin is a member of the transforming growth factor β superfamily of secreted growth
factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have …