Click chemistry strategies for the accelerated synthesis of functional macromolecules

Z Geng, JJ Shin, Y Xi, CJ Hawker - Journal of Polymer Science, 2021 - Wiley Online Library
Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

Amphiphilic copolymers in biomedical applications: Synthesis routes and property control

F Perin, A Motta, D Maniglio - Materials Science and Engineering: C, 2021 - Elsevier
The request of new materials, matching strict requirements to be applied in precision and
patient-specific medicine, is pushing for the synthesis of more and more complex block …

A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

M Zhang, X Peng, Y Ding, X Ke, K Ren, Q Xin… - Materials …, 2023 - pubs.rsc.org
Enhanced joint synergistic lubrication combined with anti-inflammatory therapy is an
effective strategy to delay the progression of early osteoarthritis (OA) but has been rarely …

Tumor acidic microenvironment-induced drug release of RGD peptide nanoparticles for cellular uptake and cancer therapy

Z Gong, X Liu, B Zhou, G Wang, X Guan, Y Xu… - Colloids and Surfaces B …, 2021 - Elsevier
Spatial accuracy is crucial in drug delivery, especially to increase the efficacy and reduce
the side effects of antitumor drugs. In this study, we developed a simple and broadly …

Topological polymer chemistry enters materials science: expanding the applicability of cyclic polymers

M Romio, L Trachsel, G Morgese… - ACS Macro …, 2020 - ACS Publications
Polymer-topology effects can alter technologically relevant properties when cyclic
macromolecules are applied within diverse materials formulations. These include coatings …

Bottlebrush polymers based on RAFT and the “C1” Polymerization method: controlled synthesis and application in anticancer drug delivery

MQ Wang, H Zou, WB Liu, N Liu, ZQ Wu - ACS Macro Letters, 2022 - ACS Publications
In this work, we reported a strategy to synthesize well-defined bottlebrush polymers.
Diazoacetate macromonomers of polystyrene (1-PS n) with controlled molecular weights …

Cyclic vs Linear Bottlebrush Polymers in Solution: Side-Chain Length Effect

G Chen, EE Dormidontova - Macromolecules, 2023 - ACS Publications
Bottlebrush polymers (BBPs) of different architecture are of considerable interest for a broad
range of applications, including nanomedicine, electronics, and self-healing materials …

Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities

F Adeli, F Abbasi, P Ghandforoushan, HE Külahlı… - Nano Today, 2023 - Elsevier
The applications of nanotechnology in medical sciences, especially in drug and gene
delivery, has experienced unprecedented growth in recent years. The integration of …

Enhanced fire safety and mechanical properties of epoxy resin composites based on submicrometer-sized rod-structured methyl macrocyclic silsesquioxane sodium …

X Ye, J Li, W Zhang, YT Pan, R Yang, J Li - Chemical Engineering Journal, 2021 - Elsevier
Facile synthesis of multifunctional macromolecules endowed with low cost has always been
a considerable challenge for chemists. Herein, a series of methyl macrocyclic oligomeric …

Multicyclic topology-enhanced anticancer drug delivery

W Ma, GY Kang, L Sun, C Meng, Y Liu, Z Zheng… - Journal of Controlled …, 2022 - Elsevier
Inspired by the biological use of a combination of precision and self-assembly to achieve
exquisite control and diversity from 20 natural amino acids, there is considerable scope for …