Advances and challenges in therapeutic targeting of NRF2

AT Dinkova-Kostova, IM Copple - Trends in pharmacological sciences, 2023 - cell.com
Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

AA Ordonez, CK Bullen, AF Villabona-Rueda… - Communications …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …

Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases

MJ Kim, JH Jeon - International Journal of Molecular Sciences, 2022 - mdpi.com
Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

Normal and pathological NRF2 signalling in the central nervous system

T Heurtaux, DS Bouvier, A Benani, S Helgueta Romero… - Antioxidants, 2022 - mdpi.com
The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master
regulator of antioxidant cellular response, but in the time since, numerous important …

The regulatory effect of phytochemicals on chronic diseases by targeting Nrf2-ARE signaling pathway

WJ He, CH Lv, Z Chen, M Shi, CX Zeng, DX Hou, S Qin - Antioxidants, 2023 - mdpi.com
Redox balance is essential to maintain the body's normal metabolism. Once disrupted, it
may lead to various chronic diseases, such as diabetes, neurodegenerative diseases …

The antioxidant transcription factor Nrf2 in cardiac ischemia–reperfusion injury

A Mata, S Cadenas - International journal of molecular sciences, 2021 - mdpi.com
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular
defense responses against toxic and oxidative stress by modulating the expression of genes …

Reactive oxygen species and antioxidative defense in chronic obstructive pulmonary disease

A Taniguchi, M Tsuge, N Miyahara, H Tsukahara - Antioxidants, 2021 - mdpi.com
The respiratory system is continuously exposed to endogenous and exogenous oxidants.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of …

Insights into the molecular mechanisms of NRF2 in kidney injury and diseases

DW Lin, YC Hsu, CC Chang, CC Hsieh… - International Journal of …, 2023 - mdpi.com
Redox is a constant phenomenon in organisms. From the signaling pathway transduction to
the oxidative stress during the inflammation and disease process, all are related to reduction …