Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …

In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment
for insulin biosynthesis, which accounts for half of the total protein production in these cells …

Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

Intrahepatic islet transplantation provides a potentially more benign alternative to pancreatic
transplantation. However, islet transplants are associated with limited engraftment potential …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

Recent years have witnessed the expansion of tissue failures and diseases. The uprising of
regenerative medicine converges the sight onto stem cell-biomaterial based therapy. Tissue …

Islet transplantation is a promising alternative therapy for insulin-dependent patients, with
the potential to eliminate life-threatening hypoglycemic episodes and secondary …

Endogenous pancreatic islets have a dense glomerular-like angioarchitecture, which
ensures an optimal delivery of oxygen and nutrients to the islet cells, provides signals from …

At present, proven clinical treatments but no cures are available for diabetes, a global
epidemic with a huge economic burden. Transplantation of islets of Langerhans by their …

Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up
approach for re-engineering the molecular landscape of cell surfaces with spatially …