Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion
gene resulting from the t (9; 22)(q34; q11) chromosomal translocation, is thought to be the …

Small molecule therapy is a critical component of targeted anticancer treatment, with
tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic …

Leukemia stem cells are a rare population with a primitive progenitor phenotype that can
initiate, sustain, and recapitulate leukemia through a poorly understood mechanism of self …

Philadelphia chromosome‐positive (Ph‐positive) acute lymphoblastic leukemia (ALL) is a
biologically, clinically, and genetically distinct subtype of precursor‐B ALL. The Ph …

Cancer immunotherapy is a promising and effective treatment modality for patients with
cancers. Cytokine, anticytokine, and antibody therapies appear to be effective in treating …

PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor
suppressor in the development of myeloid malignancies, in particular acute myeloid …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role
in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to …

The tumor suppressive function of PTEN is exerted within 2 different cellular compartments.
In the cytosol-membrane, it negatively regulates PI3K-AKT pathway through the de …

Glycogen synthase kinase-3 (GSK-3) is an evolutionarily conserved, ubiquitously
expressed, multifunctional serine/threonine protein kinase involved in the regulation of a …

Nuclear factor κB (NF‑κB) is an essential component of tumorigenesis and resistance to
cancer treatments. NFKB inhibitor α (IκB‑α) acts as a negative regulator of the classical NF …