Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

The α-helix is pre-eminent in structural biology and widely exploited in protein folding,
design and engineering. Although other helical peptide conformations do exist near to the α …

Heterotrimeric G-proteins (Gαβγ) are the main transducers of signals from GPCRs,
mediating the action of countless natural stimuli and therapeutic agents. However, there are …

Human noroviruses cause acute foodborne gastroenteritis outbreaks worldwide. In this
study, a highly sensitive and selective electrochemical biosensor was fabricated for the …

We test a range of standard generalized Born (GB) models and protein force fields for a set
of five experimentally characterized, designed peptides comprising alternating blocks of …

Linkers play critical roles in the construction of synthetic protein switches and sensors as
they functionally couple a receptor with an actuator. With an increasing number of molecular …

We report on GCaMP-Rs, a new family of genetically encoded ratiometric calcium indicators
that extend the virtues of the GCaMP proteins to ratiometric measurements. We have …

At presynaptic active zones, arrays of large conserved scaffold proteins mediate fast and
temporally precise release of synaptic vesicles (SVs). SV release sites could be identified by …