P450c17 commands a central role in human steroidogenesis as the qualitative regulator of
steroid hormone flux (Fig. 1). Analysis of P450c17 deficiencies in humans illustrates many …

The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

Context: Products of at least five specific steroidogenic genes, including steroidogenic acute
regulatory protein (StAR), which facilitates the entry of cytosolic cholesterol into the …

Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms
underpinning their synthesis, secretion, and mode of action in normal physiology is essential …

Background: 17-Hydroxyprogesterone (17-OHP) can be converted to dihydrotestosterone
(DHT) via an alternative “backdoor” route that bypasses the conventional intermediates …

Abstract Cytochrome b5, a 17‐kDa hemeprotein associated primarily with the endoplasmic
reticulum of eukaryotic cells, has long been known to augment some cytochrome P450 …

Drug oxidation activities of 12 recombinant human cytochrome P450s (P450) coexpressed
with human NADPH-P450 reductase (NPR) in bacterial membranes (P450/NPR …

The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the
biochemistry and molecular biology of these processes are still being studied. This chapter …

Androgen excess (AE) is a key feature of polycystic ovary syndrome (PCOS) and results in,
or contributes to, the clinical phenotype of these patients. Although AE will contribute to the …

Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase deficiency (21OHD)
has a worldwide incidence of 1 in 15–20,000. Affected individuals have adrenal insufficiency …