ABSTRACT The cytochrome P450 (P450) field came out of interest in the metabolism of
drugs, carcinogens, and steroids, which remain major focal points. Over the years we have …

Abstract P450c17 (17α-hydroxylase/17, 20-lyase) catalyzes steroid 17α-hydroxylase and 17,
20-lyase activities in the biosynthesis of androgens and estrogens. These two activities are …

Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting 4%–8% of
reproductive-aged women. The syndrome is characterized by hyperandrogenemia and …

Androgens and estrogens are made from dehydroepiandrosterone (DHEA), which is made
from cholesterol via four steps. First, cholesterol enters the mitochondria with the assistance …

This article reviews in vitro metabolic activities [including Michaelis constants (K m), maximal
velocities (V max) and V max/K m] and drug–steroid interactions [such as induction and …

Adrenarche reflects the maturation of the adrenal zona reticularis resulting in increased
secretion of the adrenal androgen precursor DHEA and its sulphate ester DHEAS …

The human cytochrome P450 17A1 (CYP17A1) enzyme operates at a key juncture of human
steroidogenesis, controlling the levels of mineralocorticoids influencing blood pressure …

We have previously shown that hexarelin, a novel GH-releasing peptide (GHRP), is able to
elicit GH release when administered iv, sc or by mouth and that it is a more potent GH …

Tissue-specific expression of steroidogenic enzymes allows the modulation of active steroid
levels in a local manner. Thus, the measurement of local steroid concentrations, rather than …

The brain, like the gonads, adrenal glands, and placenta, is a steroidogenic organ. The
steroids synthesized by the brain and by the nervous system, given the name neurosteroids …