The 17, 20-Lyase Activity of Cytochrome P450c17 from Human Fetal Testis Favors the Δ5 Steroidogenic Pathway
Cytochrome P450c17 catalyzes both 17α-hydroxylation and 17, 20-lyase conversion of 21-
carbon steroids to 19-carbon precursors of sex steroids. P450c17 can mediate testosterone …
carbon steroids to 19-carbon precursors of sex steroids. P450c17 can mediate testosterone …
Steroid biosynthesis and prostate cancer
N Sharifi, RJ Auchus - Steroids, 2012 - Elsevier
The pathways of androgen biosynthesis in human beings have been studied for decades,
and the major pathways and enzymes responsible for testosterone and dihydrotestosterone …
and the major pathways and enzymes responsible for testosterone and dihydrotestosterone …
Plasticity of specialized metabolism as mediated by dynamic metabolons
The formation of specialized metabolites enables plants to respond to biotic and abiotic
stresses, but requires the sequential action of multiple enzymes. To facilitate swift production …
stresses, but requires the sequential action of multiple enzymes. To facilitate swift production …
5α-androstane-3α, 17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α, 17α-diol-20-one as a key intermediate
JD Wilson, RJ Auchus, MW Leihy, OL Guryev… - …, 2003 - academic.oup.com
The synthetic pathway by which 5α-androstane-3α, 17β-diol (5α-adiol) is formed in the
testes of tammar wallaby pouch young was investigated by incubating testes from d 20–40 …
testes of tammar wallaby pouch young was investigated by incubating testes from d 20–40 …
Regulation of 17, 20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17
Cytochrome P450c17 catalyzes the 17α-hydroxylase activity required for glucocorticoid
synthesis and the 17, 20 lyase activity required for sex steroid synthesis. Most P450 …
synthesis and the 17, 20 lyase activity required for sex steroid synthesis. Most P450 …
Functional zonation of the adult mammalian adrenal cortex
GP Vinson - Frontiers in Neuroscience, 2016 - frontiersin.org
The standard model of adrenocortical zonation holds that the three main zones,
glomerulosa, fasciculata, and reticularis each have a distinct function, producing …
glomerulosa, fasciculata, and reticularis each have a distinct function, producing …
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase
Androgen biosynthesis requires 3β-hydroxysteroid dehydrogenase type II (3βHSDII) and the
17α-hydroxylase and 17, 20-lyase activities of cytochrome P450c17. Thiazolidinedione and …
17α-hydroxylase and 17, 20-lyase activities of cytochrome P450c17. Thiazolidinedione and …
P450c17 Mutations R347H and R358Q Selectively Disrupt 17,20-Lyase Activity by Disrupting Interactions with P450 Oxidoreductase and Cytochrome b5
Cytochrome P450c17 catalyzes steroid 17α-hydroxylase and 17, 20-lyase activities and
hence is a key enzyme in the production of human glucocorticoids and sex steroids. These …
hence is a key enzyme in the production of human glucocorticoids and sex steroids. These …
Cytochromes p450: roles in diseases
IA Pikuleva, MR Waterman - Journal of Biological Chemistry, 2013 - ASBMB
The cytochrome P450 superfamily consists of a large number of heme-containing
monooxygenases. Many human P450s metabolize drugs used to treat human diseases …
monooxygenases. Many human P450s metabolize drugs used to treat human diseases …
Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development
M Fukami, K Homma, T Hasegawa… - Developmental …, 2013 - Wiley Online Library
We review the current knowledge about the “backdoor” pathway for the biosynthesis of
dihydrotestosterone (DHT). While DHT is produced from cholesterol through the …
dihydrotestosterone (DHT). While DHT is produced from cholesterol through the …