Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …

Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

The goal of this review was to assess the effectiveness of ketogenic diets on the therapy of
neurodegenerative diseases. The ketogenic diet is a low-carbohydrate and fat-rich diet. Its …

Gut microbiome is a community of microorganisms in the gastrointestinal tract. These
bacteria have a tremendous impact on the human physiology in healthy individuals and …

Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …

Abstract Background Approximately 70% of Alzheimer's disease (AD) patients have co-
morbid vascular contributions to cognitive impairment and dementia (VCID); this highly …

Obesity is linked to increased risk for and severity of Alzheimer's disease (AD). Cerebral
blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We …