[HTML][HTML] p38 MAPK signaling in osteoblast differentiation

E Rodríguez-Carballo, B Gámez… - Frontiers in cell and …, 2016 - frontiersin.org
The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

[HTML][HTML] A review of the latest insights into the mechanism of action of strontium in bone

D Marx, AR Yazdi, M Papini, M Towler - Bone reports, 2020 - Elsevier
Interest in strontium (Sr) has persisted over the last three decades due to its unique
mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast …

Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis

Z Saidak, PJ Marie - Pharmacology & therapeutics, 2012 - Elsevier
Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

A promising wound dressing material with excellent cytocompatibility and proangiogenesis action for wound healing: Strontium loaded Silk fibroin/Sodium alginate …

S Li, L Li, C Guo, H Qin, X Yu - International journal of biological …, 2017 - Elsevier
Effectively stimulating angiogenesis is great challenge in wound care management. It's
necessary to develop a new wound dressing with angiogenic capacity. Therefore, strontium …

[HTML][HTML] Strontium functionalization of biomaterials for bone tissue engineering purposes: a biological point of view

G Borciani, G Ciapetti, C Vitale-Brovarone, N Baldini - Materials, 2022 - mdpi.com
Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection
to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of …

Bioactive glasses entering the mainstream

S Kargozar, F Baino, S Hamzehlou, RG Hill… - Drug discovery today, 2018 - Elsevier
Highlights•BGs act as versatile drug delivery systems with a wide range of biomedical
applications.•Release of therapeutic ions from BGs results in desired effects in biological …

[HTML][HTML] Biological roles and delivery strategies for ions to promote osteogenic induction

E Bosch-Rué, L Diez-Tercero… - Frontiers in cell and …, 2021 - frontiersin.org
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic
capability to regenerate upon injury, several pathologies and injuries could hamper the …

[HTML][HTML] Osteogenesis capability of three-dimensionally printed poly (lactic acid)-halloysite nanotube scaffolds containing strontium ranelate

SBA Boraei, J Nourmohammadi, FS Mahdavi… - Nanotechnology …, 2022 - degruyter.com
In this study, three-dimensional (3D) printing of 3D scaffolds containing halloysite nanotubes
(HNTs) and strontium ranelate (SrR) as a carrier for the promotion of bone regeneration is …

Osteogenic, anti-osteoclastogenic and immunomodulatory properties of a strontium-releasing hybrid scaffold for bone repair

AH Lourenco, AL Torres, DP Vasconcelos… - Materials Science and …, 2019 - Elsevier
Strontium (Sr) is known to stimulate osteogenesis, while inhibiting osteoclastogenesis, thus
encouraging research on its application as a therapeutic agent for bone repair/regeneration …

Strontium and magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model

Y Okuzu, S Fujibayashi, S Yamaguchi, K Yamamoto… - Acta biomaterialia, 2017 - Elsevier
We have previously developed the “alkali and heat treatment” method to confer bioactivity
(bone-bonding ability) to titanium metal (Ti). As strontium (Sr) and magnesium (Mg) ions …