Background: Chronic renal failure (CRF) has been shown to significantly reduce the
nonrenal clearance and alter bioavailability of drugs predominantly metabolized by the liver …

Peptides have been demonstrated as potentially beneficial compounds against several life-
style related diseases such as hypertension, hypercholesterolemia, and atherosclerosis …

The human intestinal absorption of 241 drugs was evaluated. Three main methods were
used to determine the human intestinal absorption: bioavailability, percentage of urinary …

The absorption of a drug compound through the human intestinal cell lining is an important
property for potential drug candidates. Measuring this property, however, can be costly and …

Absorption of inhibitory peptides to angiotensin I-converting enzyme, L-valyl-L-prolyl-L-
proline and L-isoleucyl-L-prolyl-L-proline, was studied in spontaneously hypertensive rats …

Mass balance excretion studies in laboratory animals and humans using radiolabeled
compounds represent a standard part of the development process for new drugs. From …

Background We have demonstrated that the antihypertensive effect of the angiotensin‐
converting enzyme inhibitor, captopril (CAP), is associated with beneficial effects on gut …

Synopsis: Captopril 1 is the first orally active inhibitor of angiotensin-converting enzyme to
become available. It has been studied to date primarily in hypertension. In mild to moderate …

1 The disposition of two angiotensin converting‐enzyme inhibitor drugs was studied in
normal volunteers. One drug was enalapril maleate (MK‐421), which requires in vivo …

Captopril, the first orally active inhibitor of angiotensin-converting enzyme, is used widely in
the treatment of hypertension and congestive heart failure. The pharmacokinetics of this …